Unconventional secretion of FABP4 by endosomes and secretory lysosomes
نویسندگان
چکیده
منابع مشابه
Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays.
Polarized response towards a contact interface is a common theme in intercellular signaling. To visualize spatial regulation of stimulated secretion within a contact region, we exposed IgE-sensitized rat basophilic leukemia (RBL) mast cells to a surface that was patterned on the microm scale with hapten-containing lipid bilayers to activate cell surface IgE-receptor complexes. We find that, wit...
متن کاملRelationship between endosomes and lysosomes.
Delivery of endocytosed macromolecules to lysosomes occurs by means of direct fusion of late endosomes with lysosomes. This has been formally demonstrated in a cell-free content mixing assay using late endosomes and lysosomes from rat liver. There is evidence from electron microscopy studies that the same process occurs in intact cells. The fusion process results in the formation of hybrid orga...
متن کاملSecretory versus degradative autophagy: unconventional secretion of inflammatory mediators.
Autophagy (macroautophagy) is often defined as a degradative process and a tributary of the lysosomal pathway. In this context, autophagy carries out cytoplasmic quality control and nutritional functions by removing defunct or disused organelles, particulate targets and invading microbes, and by bulk digestion of the cytoplasm. However, recent studies indicate that autophagy surprisingly affect...
متن کاملMitotic partitioning of endosomes and lysosomes
BACKGROUND Some of the mechanisms underlying cell division and partitioning of the cellular components into the daughter cells are well known. Within the endomembrane system, there is a general cessation of membrane traffic, including endocytosis and endosome fusion, at the onset of mitosis. However, the fate of endosomes and lysosomes during mitosis has been less well studied. RESULTS Using ...
متن کاملRegulating secretory lysosomes.
Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2017
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201705047